Drug resistant infections beat by natural compound
- David Hadley
- Technology Transfer
- (505) 667-7539
Drug resistant infections beat by naturally occurring compound
- Effective treatment of drug resistant pathogens
- Useful against a broad spectrum of bacteria
- Unique structure is amenable to synthesis
- Unique structure will make development of resistance difficult
A team of Los Alamos researchers has discovered and isolated a naturally occurring compound that is highly effective at eliminating growth of gram positive and gram negative bacteria in vitro. The team analyzed the organism that naturally produces the compound to determine the genetically encoded components if the enzymatic cluster associated with the biosynthesis of this natural product. Subsequently, using bioinformatics, this information was used to interrogate databases of known sequences from other organisms and identify similar assembly lines that produce structurally similar compounds. The natural products from these newly identified organisms are structurally different from any known antibacterials. We believe these natural produces are amenable to cost-effective chemical synthesis methodologies to increase their diversity and to provide low-cost therapeutics to treat multi-drug resistant infections.
Development stage: Multiple organisms that produce these natural products are being cultured to synthesize adequate quantities of bioactive compounds from each with which to conduct toxicological and mutagenicity studies in human cell lines.
Intellectual property status: Patent application pending.
Licensing status: Los Alamos is seeking commercial partners to co-develop the technology.